Thymoquinone
产品说明书
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同义名 : | NSC 2228 |
| CAS号 : | 490-91-5 | |
| 货号 : | A263475 | |
| 分子式 : | C10H12O2 | |
| 纯度 : | 99% | |
| 分子量 : | 164.2 | |
| MDL号 : | MFCD00001602 | |
| 存储条件： |
Pure form Sealed in dry, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Thymoquinone (TQ) is the most abundant constituent of the volatile oil of Nigella sativa seeds and has pharmacological actions including anti-oxidant, anti-inflammatory, immunomodulatory, anti-histaminic, anti-microbial and anti-tumor effects.An LD50 of 10 mg/kg for TQ when injected intraperitoneally in rats. The maximum tolerated dose for intraperitoneal injection was 22.5 mg/kg in male and 15 mg/kg in female rats, whereas for oral ingestion it was 250 mg/kg, in both male and female rats. in vitro, TQ also acted as inhibitor of COX-1 and -2, also inhibiting p38 in murine macrophages[3]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT03208790 | Premalignant Lesion | Phase 2 | Not yet recruiting | December 2019 | - |
| NCT03776448 | Diabetes Mellitus | Not Applicable | Not yet recruiting | February 2019 | Saudi Arabia ... 展开 >> Sulaiman AlRajhi Colleges Not yet recruiting Al Bukairiyah, Qassim, Saudi Arabia, 51941, PO Box 777 Contact: Nazmus Saquib, Phd 966 533445899 a.saquib@sr.edu.sa Principal Investigator: Nazmus Saquib, Phd Sub-Investigator: Ahmed Abduljalil 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
6.09mL 1.22mL 0.61mL |
30.45mL 6.09mL 3.05mL |
60.90mL 12.18mL 6.09mL |
| 参考文献 |
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