同义名 :	苦木酮
	CAS号 :	18110-86-6
	货号 :	A261403
	分子式 :	C15H10N2O3
	纯度 :	99%
	分子量 :	266.26
	MDL号 :	N/A
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

5-Hydroxy-4-methoxycanthin-6-one, a natural product isolated and purified from the barks of Picrasma quassioides (D.Don) Benn with anti-inflammatory effect and protective effect on dextran sulfate sodium -induced rat colitis, exhibits significant cytotoxic activity against CNE2 cell line, reduces the development of carrageenan-induced paw edema and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats.

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	3.76mL 0.75mL 0.38mL	18.78mL 3.76mL 1.88mL	37.56mL 7.51mL 3.76mL

参考文献
[1]Liu JF, Shao M, et al. Protective effect of 4-methoxy-5-hydroxycanthin-6-one, a natural alkaloid, on dextran sulfate sodium-induced rat colitis. Planta Med. 2009 Feb;75(2):142-5. [2]Jiang MX, Zhou YJ. Canthin-6-one alkaloids from Picrasma quassioides and their cytotoxic activity. J Asian Nat Prod Res. 2008 Nov-Dec;10(11-12):1009-12.