1-(2,3-Dichlorophenyl)ethanamine HCl

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Chemical Structure| 39959-66-5 同义名 : -
CAS号 : 39959-66-5
货号 : A254512
分子式 : C8H10Cl3N
纯度 : 97%
分子量 : 226.53
MDL号 : MFCD00055225
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Phenylethanolamine-N-methyltransferase (PNMT) is an enzyme that catalyzes the final step of the biosynthesis of epinephrine from norepinephrine. LY 78335 is a PNMT inhibitor with a Ki value of 0.09μM in vitro. The half-life of LY 78335 in rat adrenal glands after injection of a dose of 0.2mmol/kg was 3.4 hours. Treatment of rats with 0.2mmol/kg LY 78335 1 hour before forced exercise led to a significant reduction in the epinephrine level compared with the saline-treated controls[1]. Treatment of mice with 25mg/kg LY 78335 resulted in dose-related reductions in exploratory head-dipping in the hold-board test without affecting locomotor activity[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.41mL

0.88mL

0.44mL

22.07mL

4.41mL

2.21mL

44.14mL

8.83mL

4.41mL
参考文献

[1]References are publications that support the biological activity of the product. Fuller et al (1973) Inhibition of phenylethanolamine N-methyltransferase by benzylamines. 2. In vitro and in vivo studies with 2,3-dichloro-α-methylbenzylamine. J.Med.Chem. 16 106 PMID: 4683104 Terry et al (1982) Regulation of episodic GH secretion by the central epinephrine system. J.Clin.Invest. 69 104 PMID: 7054231 Grunewald et al (1988) Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase. J.Med.Chem. 31 824 PMID: 3351861 If you know of a relevant reference for LY 78335, please let us know.

[2]Fuller RW, Roush BW, Snoddy HD, Molloy BB. Inhibition of phenylethanolamine N-methyltransferase by benzylamines. 2. In vitro and in vivo studies with 2,3-dichloro-methylbenzylamine. J Med Chem. 1973 Feb;16(2):106-9.

[3]Durcan MJ, Lister RG, Linnoila M. Behavioral effects of the inhibitors of phenylethanolamine-N-methyltransferase, LY 78335 and LY 134046, and their interactions with ethanol. Psychopharmacology (Berl). 1990;101(2):196-202.