同义名 :	盐酸阿考替胺 ;Acotiamide hydrochloride; YM-443 HCl; Z-338 HCl; Acotiamide monohydrochloride trihydrate
	CAS号 :	773092-05-0
	货号 :	A254230
	分子式 :	C21H37ClN4O8S
	纯度 :	99%
	分子量 :	541.06
	MDL号 :	MFCD28101055
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Acotiamide hydrochloride trihydrate is a novel gastroprokinetic drug. It enhances acetylcholine released by enteric neurons through muscarinic receptor antagonism and acetylcholinesterase (AChE) inhibition, thereby enhancing gastric emptying and gastric accommodation[1]. Acotiamide inhibited AChE activity in vitro with a 50% inhibitory concentration of 1.79 μM. ACh reached the maximum concentration at 2 h after administration[2].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	1.85mL 0.37mL 0.18mL	9.24mL 1.85mL 0.92mL	18.48mL 3.70mL 1.85mL

参考文献

[1]Nowlan ML, Scott LJ. Acotiamide: first global approval. Drugs. 2013 Aug;73(12):1377-83. doi: 10.1007/s40265-013-0100-9. Erratum in: Drugs. 2014 Jun;74(9):1059. Nolan, Mary L [corrected to Nowlan, Mary L]. [2]Yoshii K, Iikura M, Hirayama M, Toda R, Kawabata Y. Physiologically-Based Pharmacokinetic and Pharmacodynamic Modeling for the Inhibition of Acetylcholinesterase by Acotiamide, A Novel Gastroprokinetic Agent for the Treatment of Functional Dyspepsia, in Rat Stomach. Pharm Res. 2016 Feb;33(2):292-300.