同义名 :	维生素B6 ;Pyridoxol; Vitamin B6; Gravidox
	CAS号 :	65-23-6
	货号 :	A251506
	分子式 :	C8H11NO3
	纯度 :	98%
	分子量 :	169.17
	MDL号 :	MFCD00006335
	存储条件：	Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Vitamin B6 (pyridoxine) is closely associated with the functions of the nervous, immune and endocrine systems. It also participates in the metabolic processes of proteins, lipids and carbohydrates. Pyridoxine deficiency may result in neurological disorders including convulsions and epileptic encephalopathy and may lead to infant abnormalities[2]. Large doses of pyridoxine cause injury to the primary sensory neurons in trigeminal and dorsal root ganglia of animals and patients subjected to megavitamin therapy. The vitamers related to pyridoxine (pyridoxal, pyridoxamine) and the coenzyme (pyridoxal 5-phosphate) did not cause clinical signs or lesions similar to those produced by pyridoxine even when injected in maximum tolerated doses[3]. Evidence, obtained with in situ perfused rat liver, indicated that pyridoxine is taken up from the perfusate by a non-concentrative process, followed by metabolic trapping[4].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	5.91mL 1.18mL 0.59mL	29.55mL 5.91mL 2.96mL	59.11mL 11.82mL 5.91mL

参考文献

[2]Ahmad I, Mirza T, Qadeer K, Nazim U, Vaid FH. Vitamin B6: deficiency diseases and methods of analysis. Pak J Pharm Sci. 2013 Sep;26(5):1057-69 [3]Levine S, Saltzman A. Pyridoxine (vitamin B6) neurotoxicity: enhancement by protein-deficient diet. J Appl Toxicol. 2004 Nov-Dec;24(6):497-500 [4]Mehansho H, Buss DD, Hamm MW, Henderson LM. Transport and metabolism of pyridoxine in rat liver. Biochim Biophys Acta. 1980 Aug 1;631(1):112-23