2-PMPA
产品说明书
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同义名 : | 2-(Phosphonomethyl)pentanedioic acid |
| CAS号 : | 173039-10-6 | |
| 货号 : | A250784 | |
| 分子式 : | C6H11O7P | |
| 纯度 : | 95% | |
| 分子量 : | 226.12 | |
| MDL号 : | MFCD00940167 | |
| 存储条件： |
Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | 2-PMPA stands out as a highly effective and specific GCPII inhibitor, an enzyme responsible for breaking down the widely present neuropeptide NAAG into NAA and glutamate, with IC50 value of 300 pM. It has shown considerable success in a variety of animal models for neurological disorders. Due to its high polarity and several negative charges, 2-PMPA presents substantial analytical challenges in biological matrices[1]. 2-PMPA mitigates the reduction in cell viability and the elevation of LDH levels caused by ketamine in mixed cell cultures, while these effects are not observed in neuronal cultures alone[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
4.42mL 0.88mL 0.44mL |
22.11mL 4.42mL 2.21mL |
44.22mL 8.84mL 4.42mL |
| 参考文献 |
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