Seladelpar

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Chemical Structure| 851528-79-5 同义名 : MBX-8025; RWJ-800025
CAS号 : 851528-79-5
货号 : A246921
分子式 : C21H23F3O5S
纯度 : 99%+
分子量 : 444.46
MDL号 : MFCD28502443
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Seladelpar (MBX-8025) is an orally administered, highly potent (with an EC50 of 2 nM), and selective agonist of the PPAR-δ receptor[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.25mL

0.45mL

0.22mL

11.25mL

2.25mL

1.12mL

22.50mL

4.50mL

2.25mL
参考文献

[1]Bays HE, et al. MBX-8025, a novel peroxisome proliferator receptor-delta agonist: lipid and other metabolic effects in dyslipidemic overweight patients treated with and without atorvastatin. J Clin Endocrinol Metab. 2011 Sep;96(9):2889-97.

[2]Haczeyni F, et al. The selective peroxisome proliferator-activated receptor-delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice. Hepatol Commun. 2017 Jul 31;1(7):663-674.