GABA

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Chemical Structure| 56-12-2 同义名 : 4-氨基丁酸 ;4-Aminobutyric acid; Mielomade; Mielogen; DF 468; Aminalon; Piperidic acid; Gamma-aminobutyric acid; 4-Aminobutanoic acid; γ-Aminobutyric acid
CAS号 : 56-12-2
货号 : A246764
分子式 : C4H9NO2
纯度 : 98%
分子量 : 103.12
MDL号 : MFCD00008226
存储条件：

Pure form Keep in dark place, inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 4-Aminobutyric acid (γ-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors)[3]. Incubation of rat brain 4-aminobutyrate aminotransferase (0.1 mM) with 4-amino-hex-5-enoic acid results in a time-dependent irreversible loss of enzymatic activity.[4]. GME (4-Aminobutyric methyl ester hydrochloride) is hydrolyzed to 4-aminobutyric acid (GABA) by brain homogenates, acts as an inhibitor of GABA binding to crude synaptic plasma membranes, activates the release and inhibits the uptake of GABA by rat synaptosomes and acts as a competitive inhibitor of the so-called GABAse system in vitro[5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02330094 Aneurysmal Subarachnoid Hemorr... 展开 >>hage 收起 << Phase 4 Completed - United States, Florida ... 展开 >> Mayo Clinic in Florida Jacksonville, Florida, United States, 32224 收起 <<
NCT02349477 Alcohol Use Disorder ... 展开 >> Alcohol Withdrawal 收起 << Phase 2 Active, not recruiting December 2018 United States, South Carolina ... 展开 >> Medical University of South Carolina Charleston, South Carolina, United States, 29425 收起 <<
NCT00312260 Pain Phase 3 Unknown December 2016 Canada, Ontario ... 展开 >> The Hospital for Sick Children Toronto, Ontario, Canada, M5G 1X8 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

9.70mL

1.94mL

0.97mL

48.49mL

9.70mL

4.85mL

96.97mL

19.39mL

9.70mL
参考文献

[1]Soltani N, Qiu H, et al. GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11692-7.

[2]Takehara A, Hosokawa M, et al. Gamma-aminobutyric acid (GABA) stimulates pancreatic cancer growth through overexpressing GABAA receptor pi subunit. Cancer Res. 2007 Oct 15;67(20):9704-12.

[3]Kowalczyk P, Kulig K. GABA system as a target for new drugs. Curr Med Chem. 2014;21(28):3294-309.

[4]Lippert B, Metcalf BW, Jung MJ, Casara P. 4-amino-hex-5-enoic acid, a selective catalytic inhibitor of 4-aminobutyric-acid aminotransferase in mammalian brain. Eur J Biochem. 1977 Apr 15;74(3):441-5.

[5]Bianchi M, Deana R, Quadro G, Mourier G, Galzigna L. 4-aminobutyric acid methyl ester hydrochloride, a precursor of 4-aminobutyric acid. Biochem Pharmacol. 1983 Mar 15;32(6):1093-6