Verubecestat TFA

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Chemical Structure| 2095432-65-6 同义名 : MK-8931 TFA; Verubecestat Trifluoroacetate; MK-8931
CAS号 : 2095432-65-6
货号 : A246701
分子式 : C19H18F5N5O5S
纯度 : 99%+
分子量 : 523.43
MDL号 : MFCD28963974
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Verubecestat (MK-8931) TFA is an orally active, high-affinity BACE1 and BACE2 inhibitor with Ki values of 2.2 nM and 0.38 nM, which effectively reduces Aβ40 and has the potential for Alzheimer's Disease[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.91mL

0.38mL

0.19mL

9.55mL

1.91mL

0.96mL

19.10mL

3.82mL

1.91mL
参考文献

[1]Yan R, et al. Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs. Transl Neurodegener. 2016 Jul 14;5:13.

[2]Scott JD, et al. Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer'sDisease. Med Chem. 2016 Dec 8;59(23):10435-10450.