CP21R7

产品说明书

Print
Chemical Structure| 125314-13-8 同义名 : CP21
CAS号 : 125314-13-8
货号 : A246592
分子式 : C19H15N3O2
纯度 : 99%+
分子量 : 317.34
MDL号 : MFCD30343845
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 CP21R7 is a selective GSK-3β inhibitor, exhibiting an IC50 of 1.8 nM; in contrast, its IC50 against PKCα is 1900 nM[1]. When used at a concentration of 3 μM, CP21R7 robustly activates the canonical Wnt signaling pathway to its highest level. It also significantly boosts the total intracellular levels of β-catenin. Moreover, when combined with BMP4, CP21R7 prompts the differentiation of human pluripotent stem cells (hPSCs) into mesoderm[2].
作用机制 CP21R7 may occupy the ATP binding pocket.[1]
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.15mL

0.63mL

0.32mL

15.76mL

3.15mL

1.58mL

31.51mL

6.30mL

3.15mL
参考文献

[1]Gong L, Hirschfeld D, et al. Discovery of potent and bioavailable GSK-3beta inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1693-6.

[2]Patsch C, Challet-Meylan L, et al. Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nat Cell Biol. 2015 Aug;17(8):994-1003.