Panobinostat lactate
产品说明书
 |
同义名 : | LBH589 lactate; NVP-LBH589 lactate |
| CAS号 : | 960055-56-5 | |
| 货号 : | A244814 | |
| 分子式 : | C24H29N3O5 | |
| 纯度 : | 97% | |
| 分子量 : | 439.5 | |
| MDL号 : | N/A | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Panobinostat lactate is a potent, orally active, non-selective HDAC inhibitor.Panobinostat lactate has antitumour activity. It is also effective in disrupting HIV latency.Panobinostat lactate induces apoptosis and autophagy and may be used in the study of refractory or recurrent multiple myeloma[1][2][3][4][5].Panobinostat lactate induces apoptosis in MOLT-4 and Reh cells in a time- and dose-dependent manner, leading to hyperacetylation of histones (H3K9 and H4K8) and regulation of cell cycle control genes in Reh cells [1].Panobinostat lactate showed potent antiproliferative activity in human NSCLC cell lines with IC50 values ranging from 5 to 100 nM [2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.28mL 0.46mL 0.23mL |
11.38mL 2.28mL 1.14mL |
22.75mL 4.55mL 2.28mL |
