Almitrine Bismesylate
产品说明书
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同义名 : | 甲磺酸阿米三嗪 ;Almitrine dimesylate; Almitrine bismethanesulfonate; Almitrine dimethanesulfonate; Almitrine mesylate |
| CAS号 : | 29608-49-9 | |
| 货号 : | A242169 | |
| 分子式 : | C28H37F2N7O6S2 | |
| 纯度 : | 98%+ | |
| 分子量 : | 669.76 | |
| MDL号 : | MFCD01679060 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
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| 描述 | Almitrine mesylate, a peripheral chemoreceptor agonist, inhibits selectively the Ca2+-dependent K+ channel. Almitrine at concentrations up to 10 mM did not affect whole-cell voltage-dependent K+, Ca2+, or Na+ currents in rat or rabbit cells. However, this concentration of almitrine significantly inhibited the Ca2+-dependent component of K+ currents in rat chemoreceptor cells. Almitrine inhibits the activity of a high-conductance (152±13 pS), Ca2+-dependent K+ channel by decreasing its open probability, with IC50 value of 0.22 μM. The inhibitory effect of almitrine on Ca2+-dependent K+ channels was also observed in GH3 cells[1]. Almitrine acts via the peripheral arterial chemoreceptors raising carotid sinus nerve output and minute ventilation. Almitrine also has a pulmonary vascular action causing a dose-dependent constriction and dilatation. At low doses Almitrine enhances hypoxic pulmonary vasoconstriction and may improve the overall ventilation/perfusion ratio[2]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.49mL 0.30mL 0.15mL |
7.47mL 1.49mL 0.75mL |
14.93mL 2.99mL 1.49mL |
| 参考文献 |
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