同义名 :	Flavoayamenin
	CAS号 :	72063-39-9
	货号 :	A241724
	分子式 :	C28H32O15
	纯度 :	99%+
	分子量 :	608.54
	MDL号 :	MFCD09754430
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Spinosin is a C-glycoside flavonoid isolated from the seeds of Zizyphus jujuba var. spinosa. Spinosin (10 or 20mg/kg, p.o.) significantly ameliorated scopolamine-induced cognitive impairment in these behavioral tasks with a prolonged latency time in the passive avoidance task, an increased percentage of spontaneous alternation in the Y-maze task and a lengthened swimming time in target quadrant in the Morris water maze task. In addition, spinosin significantly increased the expression levels of phosphorylated extracellular signal-regulated kinases and cAMP response element-binding proteins in the hippocampus[3]. Spinosin reduced Aβ1-42 production by activating the Nrf2/HO-1 pathway in N2a/WT (Wild type mouse Neuro-2a cells) and N2a/ APP695 cells[4]. Spinosin improves synaptic function in the AD hippocampus by regulating plasmin activity[5].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	1.64mL 0.33mL 0.16mL	8.22mL 1.64mL 0.82mL	16.43mL 3.29mL 1.64mL

参考文献

[1]Ko SY, Lee HE, et al. Spinosin, a C-Glucosylflavone, from Zizyphus jujuba var. spinosa Ameliorates Aβ1-42 Oligomer-Induced Memory Impairment in Mice. Biomol Ther (Seoul). 2015 Mar;23(2):156-64. [2]Liu J, Zhai WM, et al. GABA and 5-HT systems are implicated in the anxiolytic-like effect of spinosin in mice. Pharmacol Biochem Behav. 2015 Jan;128:41-9. [3]Jung IH, Lee HE, Park SJ, Ahn YJ, Kwon G, Woo H, Lee SY, Kim JS, Jo YW, Jang DS, Kang SS, Ryu JH. Ameliorating effect of spinosin, a C-glycoside flavonoid, on scopolamine-induced memory impairment in mice. Pharmacol Biochem Behav. 2014 May;120:88-94 [4]Zhang X, Wang J, Gong G, Ma R, Xu F, Yan T, Wu B, Jia Y. Spinosin Inhibits Aβ1-42 Production and Aggregation via Activating Nrf2/HO-1 Pathway. Biomol Ther (Seoul). 2020 May 1;28(3):259-266 [5]Cai M, Jung I, Kwon H, Cho E, Jeon J, Yun J, Lee YC, Kim DH, Ryu JH. Spinosin Attenuates Alzheimer's Disease-Associated Synaptic Dysfunction via Regulation of Plasmin Activity. Biomol Ther (Seoul). 2020 Mar 1;28(2):131-136