BEBT-908

产品说明书

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Chemical Structure| 1235449-52-1 同义名 : PI3Kα inhibitor 1
CAS号 : 1235449-52-1
货号 : A236733
分子式 : C23H25N9O3S
纯度 : 98+%
分子量 : 507.57
MDL号 : MFCD29924723
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 BEBT-908 is a PI3Kα inhibitor with an IC50 < 0.1 μM, and also inhibits HDAC (0.1 μM ≤ IC50 ≤ 1 μM) .
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.97mL

0.39mL

0.20mL

9.85mL

1.97mL

0.99mL

19.70mL

3.94mL

1.97mL
参考文献

[1]Ibrahim MA, Abou-Seri SM, et al. Design, synthesis and biological evaluation of novel condensed pyrrolo[1,2-c] pyrimidines featuring morpholine moiety as PI3Kα inhibitors. Eur J Med Chem. 2015 Jun 24;99:1-13.

[2]Li J, Qian C, et al. BEBT-908: A novel potent PI3K/HDAC inhibitor against diffuse large B-cell lymphoma. Biochem Biophys Res Commun. 2017 Sep 30;491(4):939-945.