RQ-00203078

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Chemical Structure| 1254205-52-1 同义名 : -
CAS号 : 1254205-52-1
货号 : A231850
分子式 : C21H13ClF6N2O5S
纯度 : 99%+
分子量 : 554.85
MDL号 : MFCD29049510
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 RQ-00203078, a potent, orally active, and highly selective antagonist of TRPM8 channels, exhibits IC50s of 5.3 nM and 8.3 nM for rat and human TRPM8 channels, respectively, while showing minimal inhibitory effects on TRPV1, TRPA1, TRPV4, and TRPM2 channels[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.80mL

0.36mL

0.18mL

9.01mL

1.80mL

0.90mL

18.02mL

3.60mL

1.80mL
参考文献

[1]Masashi Ohmi, et al. Identification of a novel 2-pyridyl-benzensulfonamide derivative, RQ-00203078, as a selective and orally active TRPM8 antagonist. Bioorg Med Chem Lett. 2014 Dec 1;24(23):5364-8.

[2]Yoshihiko Okamoto, et al. Blockade of TRPM8 activity reduces the invasion potential of oral squamous carcinoma cell lines. Int J Oncol. 2012 May;40(5):1431-40.