CNX-1351

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Chemical Structure| 1276105-89-5 同义名 : -
CAS号 : 1276105-89-5
货号 : A225035
分子式 : C30H35N7O3S
纯度 : 99%+
分子量 : 573.71
MDL号 : MFCD25976872
存储条件：

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 CNX-1351 is a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kα with IC50 of 6.8 nM and 20-400 times less potent against β, γ, and δ.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.74mL

0.35mL

0.17mL

8.72mL

1.74mL

0.87mL

17.43mL

3.49mL

1.74mL
参考文献

[1]Nacht M, Qiao L, et al. Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kα. J Med Chem. 2013 Feb 14;56(3):712-21.