同义名 :	1-氨基环戊烷甲酸
	CAS号 :	52-52-8
	货号 :	A224871
	分子式 :	C6H11NO2
	纯度 :	98%
	分子量 :	129.16
	MDL号 :	MFCD00001381
	存储条件：	Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性
描述	Cycloleucine acts as a specific blocker of S-adenosyl-methionine dependent methylation processes and antagonizes the NMDA receptor-associated glycine receptor, evidenced by a Ki value of 600 μM. It also competitively inhibits ATP: L-methionine-S-adenosyl transferase in vitro, displaying anxiolytic and cytostatic effects[1].[2].[3].[4].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	7.74mL 1.55mL 0.77mL	38.71mL 7.74mL 3.87mL	77.42mL 15.48mL 7.74mL

参考文献

[1]Hood WF, et, al. 1-Aminocyclobutane-1-carboxylate (ACBC): a specific antagonist of the N-methyl-D-aspartate receptor coupled glycine receptor. Eur J Pharmacol. 1989 Feb 28;161(2-3):281-2. [2]Caboche M, et, al. RNA methylation and control of eukaryotic RNA biosynthesis. Effects of cycloleucine, a specific inhibitor of methylation, on ribosomal RNA maturation. Eur J Biochem. 1977 Mar 15;74(1):19-29. [3]Gargiulo API, et, al. Effects of Cycloleucine in the Nucleus Accumbens Septi on the Elevated plus Maze Test in Rats. Neuropsychobiology. 2020;79(3):191-197. [4]Duś D, et, al. Cytostatic activity in vitro of cycloleucine, aspartic acid and glutamic acid phosphonic analogues. Arch Immunol Ther Exp (Warsz). 1980;28(3):433-8. [5]Dimock K, et, al. Cycloleucine blocks 5'-terminal and internal methylations of avian sarcoma virus genome RNA. Biochemistry. 1978 Aug 22;17(17):3627-32. [6]S Amor, et al. The effect of cycloleucine on SFV A7(74) infection in mice. Br J Exp Pathol. 1987 Apr;68(2):225-35.