L-655708

产品说明书

Print
Chemical Structure| 130477-52-0 同义名 : -
CAS号 : 130477-52-0
货号 : A222609
分子式 : C18H19N3O4
纯度 : 99%
分子量 : 341.36
MDL号 : MFCD02684528
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 L-655708 is a potent α5 subunit-selective GABAA receptor inverse agonist (Ki = 0.45 nM).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.93mL

0.59mL

0.29mL

14.65mL

2.93mL

1.46mL

29.29mL

5.86mL

2.93mL
参考文献

[1]Atack JR, Bayley PJ, et al. L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for alpha5-containing GABAA receptors. Neuropharmacology. 2006 Nov;51(6):1023-9.

[2]Quirk K, Blurton P, et al. [3H] L-655,708, a novel ligand selective for the benzodiazepine site of GABAA receptors which contain the alpha 5 subunit. Neuropharmacology. 1996;35(9-10):1331-5.