CP-465022

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Chemical Structure| 199655-36-2 同义名 : -
CAS号 : 199655-36-2
货号 : A222361
分子式 : C26H24ClFN4O
纯度 : 99+%
分子量 : 462.95
MDL号 : MFCD28160468
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 CP 465022 hydrochloride is a selective, non-competitive AMPA receptor antagonist (IC50 = 25 nM in rat cortical neurons) that displays potent anticonvulsant activity.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.16mL

0.43mL

0.22mL

10.80mL

2.16mL

1.08mL

21.60mL

4.32mL

2.16mL
参考文献

[1]Menniti FS, Buchan AM, et al. CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo. Stroke. 2003 Jan;34(1):171-6.

[2]Lazzaro JT, Paternain AV, et al. Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist. Neuropharmacology. 2002 Feb;42(2):143-53.