Closantel

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Chemical Structure| 57808-65-8 同义名 : 克罗散泰 ;NSC 335306
CAS号 : 57808-65-8
货号 : A220377
分子式 : C22H14Cl2I2N2O2
纯度 : 99+%
分子量 : 663.07
MDL号 : MFCD00661151
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Closantel is a halogenated salicylanilide known for its effective anti-parasitic properties. It operates as a highly specific inhibitor of the Onchocerca volvulus chitinase (OvCHT1), showcasing an IC50 of 1.6 μM and a Ki of 468 nM, effectively blocking the developmental molt from L3 to L4 stages in O. volvulus.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.51mL

0.30mL

0.15mL

7.54mL

1.51mL

0.75mL

15.08mL

3.02mL

1.51mL
参考文献

[1]Amanda L Garner, et al. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 9;54(11):3963-72.

[2]Amanda L Garner, et al. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 9;54(11):3963-72.