同义名 :	-
	CAS号 :	1568-80-5
	货号 :	A218060
	分子式 :	C21H24O2
	纯度 :	98%
	分子量 :	308.41
	MDL号 :	MFCD01412945
	存储条件：	Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

HIV encodes three enzymes: reverse transcriptase (RT), protease (PR), and integrase (IN). IN is a promising target because integration is an essential step in retroviral replication cycle. HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor. HIV-1 integrase inhibitor 8 inhibited 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn2+ as the cationic cofactor by gel assay with IC50 values of 275 µM and 200 µM, respectively. Furthermore, HIV-1 integrase inhibitor 8 inhibited MCV (molluscum contagiosum virus) topoisomerase and DNA religation with IC50 values of 500 µM and 200 µM, respectively. Moreover, HIV-1 integrase inhibitor 8 induced cell cytotoxicity and yielded a LD50 (dose at which the signal was reduced 50% due to cell death) of 20 μM in HeLa cells[2].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	3.24mL 0.65mL 0.32mL	16.21mL 3.24mL 1.62mL	32.42mL 6.48mL 3.24mL

参考文献
[1]Molteni, et al. A New Class of HIV-1 Integrase Inhibitors: The 3,3,3', 3'-tetramethyl-1,1'-spirobi(indan)-5,5',6,6'-tetrol Family.J Med Chem [2]Molteni V, Rhodes D, Rubins K, Hansen M, Bushman FD, Siegel JS. A new class of HIV-1 integrase inhibitors: the 3,3,3', 3'-tetramethyl-1,1'-spirobi(indan)-5,5',6,6'-tetrol family. J Med Chem. 2000 May 18;43(10):2031-9.