Liquiritin apioside
产品说明书
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同义名 : | - |
| CAS号 : | 74639-14-8 | |
| 货号 : | A217043 | |
| 分子式 : | C26H30O13 | |
| 纯度 : | 98% | |
| 分子量 : | 550.51 | |
| MDL号 : | MFCD09260034 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Liquiritin apioside (LA), a main flavonoid component of licorice. Intralaryngeal LA treatment significantly attenuated the apneic response to chemical but not mechanical stimulations. LA pretreatment significantly altered the electrophysiological kinetics of CAP-induced currents in laryngeal C neurons by reducing their amplitudes, increasing the rise times, and prolonging the decay times[3]. Treatment with LA concentration-dependently prevented CSE(cigarette smoke extract)-induced cytotoxicity, increase of TGF-β and TNF-α mRNA expression, depletion of GSH and apoptosis in A549 cells. LA at doses 3, 10 and 30 mg/kg dose-dependently inhibited pulmonary neutrophil and macrophage inflammation[4]. Liquiritin apioside moderately inhibited AChE (IC50 = 36.68 µM)[5]. In addition, liquiritin and liquiritin apioside contribute as active substances for the purgative action of DKT(Daiokanzoto), and some antibiotics reduce the purgative action of DKT and sennoside A[6]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.82mL 0.36mL 0.18mL |
9.08mL 1.82mL 0.91mL |
18.16mL 3.63mL 1.82mL |
| 参考文献 |
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