同义名 :	NSC 308880
	CAS号 :	32791-84-7
	货号 :	A215146
	分子式 :	C30H52O4
	纯度 :	98%
	分子量 :	476.73
	MDL号 :	MFCD00210541
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Panaxatriol is a natural product. Panaxatriol (200 mg/kg/d, 3 weeks) can relieve myelosuppression induced by radiation injury[3]. Panaxatriol exerts dosedependent cytotoxic effects on prostate DU-15 cancer cells. The IC50 of panaxatriol was 30 μM. Additionally, panaxatriol induced sub-G1 cell cycle arrest and suppressed the DU-15 cell migration ability in a concentration-dependent manner[4]. PT (Panaxatriol) reduced tumor cell invasion through a reconstituted basement membrane in the transwell chamber. Increased GR (glucocorticoid receptor) in the nucleus of HT1080 human fibrosarcoma cells treated by PT. GR-induced down-regulation of MMP-9 by PT contributes to reduce the invasive capacity of HT1080 cells[5]. Aerobic exercise and PT (Panaxatriol) ingestion may contribute to maintain skeletal muscle mass through the amelioration of insulin resistance[6].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.10mL 0.42mL 0.21mL	10.49mL 2.10mL 1.05mL	20.98mL 4.20mL 2.10mL

参考文献

[1]Kim TH, Lee SM. The effects of ginseng total saponin, panaxadiol and panaxatriol on ischemia/reperfusion injury in isolated rat heart. Food Chem Toxicol. 2010 Jun;48(6):1516-20. [2]Liu FY, Wang JN, et al, Zhang JD. Effect of panaxatriol on hematogenesis and granulocyte-macrophage colony stimulating factor in radiation injured mice. Saudi Med J. 2007 Dec;28(12):1791-5. [3]Liu FY, Wang JN, Yu SD, Wang B, Zhang JD. Effect of panaxatriol on hematogenesis and granulocyte-macrophage colony stimulating factor in radiation injured mice. Saudi Med J. 2007 Dec;28(12):1791-5 [4]Yu R, Zhang Y, Xu Z, Wang J, Chen B, Jin H. Potential antitumor effects of panaxatriol against DU-15 human prostate cancer cells is mediated via mitochondrial mediated apoptosis, inhibition of cell migration and sub-G1 cell cycle arrest. J BUON. 2018 Jan-Feb;23(1):200-204 [5]Park MT, Cha HJ, Jeong JW, Kim SI, Chung HY, Kim ND, Kim OH, Kim KW. Glucocorticoid receptor-induced down-regulation of MMP-9 by ginseng components, PD and PT contributes to inhibition of the invasive capacity of HT1080 human fibrosarcoma cells. Mol Cells. 1999 Oct 31;9(5):476-83 [6]Takamura Y, Nomura M, Uchiyama A, Fujita S. Effects of Aerobic Exercise Combined with Panaxatriol Derived from Ginseng on Insulin Resistance and Skeletal Muscle Mass in Type 2 Diabetic Mice. J Nutr Sci Vitaminol (Tokyo). 2017;63(5):339-348