4-Methylesculetin
产品说明书
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同义名 : | - |
| CAS号 : | 529-84-0 | |
| 货号 : | A214707 | |
| 分子式 : | C10H8O4 | |
| 纯度 : | 95% | |
| 分子量 : | 192.17 | |
| MDL号 : | MFCD00006859 | |
| 存储条件： |
Pure form Sealed in dry, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | 4-Methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. 4-methylesculetin (25 mg/kg) improved microscopic parameters, decreased MPO activity, reduced the colonic levels of IL-6 and counteracted GSH depletion[1]. 4 ME (4-Methylesculetin) modulated glutathione-related enzymes, mainly increasing glutathione reductase activity. 4 ME acted by different mechanisms to control oxidative stress induced by intestinal damage, controlling the imbalance between myeloperoxidase activity and glutathione production, upregulating the glutathione S-transferase and glutathione reductase activities, preventing the Nrf2 and glutathione gene expression downregulation with consequent glutathione maintenance[2]. Further, 4-ME significantly ameliorated the upregulated non-enzymatic inflammatory markers like TNF-α, IL-1β, IL-6, COX-2 and PGE2. Besides, 4-ME effectively stabilized the arthritis-induced oxidative stress by restoring the levels of reactive oxygen species, lipid and hydro peroxides and antioxidant enzymes such as superoxide dismutase, catalase and glutathione-S-transferase[3]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
5.20mL 1.04mL 0.52mL |
26.02mL 5.20mL 2.60mL |
52.04mL 10.41mL 5.20mL |
| 参考文献 |
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