Bupivacaine

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Chemical Structure| 38396-39-3 同义名 : 布比卡因
CAS号 : 38396-39-3
货号 : A211412
分子式 : C18H28N2O
纯度 : 98%
分子量 : 288.43
MDL号 : -
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Bupivacaine is an NMDA receptor inhibitor and has the ability to block sodium, L-calcium, and potassium channels. It particularly targets SCN5A channels with an IC50 of 69.5 μM, making it a relevant agent in chronic pain research[1].[2].[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.47mL

0.69mL

0.35mL

17.34mL

3.47mL

1.73mL

34.67mL

6.93mL

3.47mL
参考文献

[1]Meaghan A Paganelli, et al. Actions of Bupivacaine, a widely used local anesthetic, on NMDA receptor responses. J Neurosci. 2015 Jan 14;35(2):831-42.

[2]Alexander P Schwoerer, et al. A Comparative Analysis of Bupivacaine and Ropivacaine Effects on Human Cardiac SCN5A Channels. Anesth Analg. 2015 Jun;120(6):1226-34.

[3]Carsten Stoetzer, et al. Inhibition of Voltage-Gated Na+ Channels by Bupivacaine Is Enhanced by the Adjuvants Buprenorphine, Ketamine, and Clonidine. Reg Anesth Pain Med.Jul/Aug 2017;42(4):462-468.