同义名 :	MPTP hydrochloride
	CAS号 :	23007-85-4
	货号 :	A211071
	分子式 :	C12H16ClN
	纯度 :	99+%
	分子量 :	209.72
	MDL号 :	MFCD00012790
	存储条件：	Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Parkinson’s disease (PD) is characterized by the selective loss of dopaminergic neurons in the substantia nigra (SN). MPTP is a neurotoxin that can induce symptoms similar to those observed in PD in humans, nonhuman primates, and mice. In addition, MPTP induces selective loss of dopaminergic neurons in mice SN[3]. Mice in the MPTP group were intraperitoneally injected with 20 mg/kg MPTP hydrochloride dissolved in saline, with four injections at 3-hour intervals over a period of 1 day. The number of tyrosine hydroxylase-immunoreactive neurons in the MPTP group was significantly lower than in the normal group (P < 0.05), indicating successful establishment of the Parkinson's disease model. The changes in thioredoxin reductase 1 protein expression in the midbrain 7 days after the last injection of MPTP were detected. The MPTP-treated mice showed a 40% decrease in thioredoxin reductase 1 protein level compared with the normal mice (P < 0.05). Moreover, there was a pronounced reduction in thioredoxin reductase 1 mRNA level in MPTP-treated mice compared with normal mice (P < 0.05)[4].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	4.77mL 0.95mL 0.48mL	23.84mL 4.77mL 2.38mL	47.68mL 9.54mL 4.77mL

参考文献

[1]Liu Z, Jing Y, et al. Downregulation of thioredoxin reductase 1 expression in the substantia nigra pars compacta of Parkinson's disease mice. Neural Regen Res. 2013 Dec 15;8(35):3275-83. [2]Nicotra A, Parvez S. Apoptotic molecules and MPTP-induced cell death. Neurotoxicol Teratol. 2002 Sep-Oct;24(5):599-605. [3]Nicotra A, Parvez S. Apoptotic molecules and MPTP-induced cell death. Neurotoxicol Teratol. 2002 Sep-Oct;24(5):599-605. doi: 10.1016/s0892-0362(02)00213-1. PMID: 12200191. [4]Liu Z, Jing Y, Yin J, Mu J, Yao T, Gao L. Downregulation of thioredoxin reductase 1 expression in the substantia nigra pars compacta of Parkinson's disease mice. Neural Regen Res. 2013 Dec 15;8(35):3275-83. doi: 10.3969/j.issn.1673-5374.2013.35.002. PMID: 25206649; PMCID: PMC4145943.