PF-04929113

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Chemical Structure| 908115-27-5 同义名 : SNX-5422
CAS号 : 908115-27-5
货号 : A210227
分子式 : C25H30F3N5O4
纯度 : 98+%
分子量 : 521.53
MDL号 : MFCD20526334
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：

0.5% CMC+0.25% Tween 80+water 25 mg/mL suspension

生物活性
描述 PF-04929113 is a potent and selective HSP90 inhibitor with Kd of 41 nM and induces Her-2 degradation with IC50 of 37 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.92mL

0.38mL

0.19mL

9.59mL

1.92mL

0.96mL

19.17mL

3.83mL

1.92mL
参考文献

[1]Huang KH, Veal JM, et al. Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents. J Med Chem. 2009 Jul 23;52(14):4288-305.

[2]Okawa Y, Hideshima T, et al. SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK. Blood. 2009 Jan 22;113(4):846-55.