Ellipticine

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Chemical Structure| 519-23-3 同义名 : NSC 71795
CAS号 : 519-23-3
货号 : A209397
分子式 : C17H14N2
纯度 : 99%+
分子量 : 246.31
MDL号 : MFCD00010524
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Ellipticine is cell-permeable antitumor alkaloid that acts as an inhibitor of topoisomerase II and acts as an intercalative agent that stimulates topoisomerase II-mediated DNA breakdown[3]. Ellipticine induced a significant decrease in MyLa2000 and SeAx cell viability at the concentration of 5-10μM (dose-dependently) and Hut-78 cells at the concentration of 20μM[4]. Ellipticine has been shown to inhibit the proliferation of human breast adenocarcinoma MCF-7 cells, leukemia HL-60 and CCRF-CEM cells, neuroblastoma IMR-32, UKF-NB-3, and UKF-NB-4 cells, and U87MG glioblastoma cells with IC50 values ranging from 0.27-4.7 µM[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.06mL

0.81mL

0.41mL

20.30mL

4.06mL

2.03mL

40.60mL

8.12mL

4.06mL
参考文献

[1]Nishiyama T, Hatae N, et al. Concise synthesis and antiproliferative activity evaluation of ellipticine quinone and its analogs. Eur J Med Chem. 2017 Aug 18;136:1-13.

[2]Stiborova M, Poljakova J, et al. Ellipticine cytotoxicity to cancer cell lines - a comparative study. Interdiscip Toxicol. 2011 Jun;4(2):98-105.

[3]Schwaller MA, Allard B, Lescot E, Moreau F. Protonophoric activity of ellipticine and isomers across the energy-transducing membrane of mitochondria. J Biol Chem. 1995;270(39):22709-22713.

[4]Savorani C, Manfé V, Biskup E, Gniadecki R. Ellipticine induces apoptosis in T-cell lymphoma via oxidative DNA damage. Leuk Lymphoma. 2015;56(3):739-747.

[5]Stiborová M, Poljaková J, Martínková E, et al. Ellipticine cytotoxicity to cancer cell lines - a comparative study. Interdiscip Toxicol. 2011;4(2):98-105.