同义名 :	珠卡赛辛 ;Zucapsaicin; Civamide
	CAS号 :	25775-90-0
	货号 :	A208947
	分子式 :	C18H27NO3
	纯度 :	95%
	分子量 :	305.41
	MDL号 :	MFCD00209942
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Zucapsaicin is a synthetic cis isomer of natural capsaicin, acts as an orally active TRPV1 agonist, which has shown therapeutic efficacy in pain accompanying osteoarthritis of the knee. Zucapsaicin significantly attenuates nociceptive behavior after oral administration in rats. (Z)-Capsaicin is also tolerated in the primary or recurrent experimental genital herpes simplex virus infection in guinea pigs[3]. Moreover, civamide (Zucapsaicin) may alter inducibility of ventricular tachycardia with focal endocardial origin and shorten APD of Purkinje fibers in vitro. The effects of civamide in vitro are prevented by pre-exposure of the Purkinje fibers to nifedipine, suggesting that the electrophysiologic effects of civamide may be mediated through blockade of calcium channels[4].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	3.27mL 0.65mL 0.33mL	16.37mL 3.27mL 1.64mL	32.74mL 6.55mL 3.27mL

参考文献

[1]Salat K, Jakubowska A, Kulig K. Zucapsaicin for the treatment of neuropathic pain. Expert Opin Investig Drugs. 2014 Oct;23(10):1433-40. [2]Schnitzer TJ, Pelletier JP, et al. Civamide cream 0.075% in patients with osteoarthritis of the knee: a 12-week randomized controlled clinical trial with a longterm extension. J Rheumatol. 2012 Mar;39(3):610-20. [3]Sałat K, Jakubowska A, Kulig K. Zucapsaicin for the treatment of neuropathic pain. Expert Opin Investig Drugs. 2014 Oct;23(10):1433-40 [4]Arnar DO, Cai JJ, Lee HC, Martins JB. Electrophysiologic effects of civamide (zucapsaicin) on canine cardiac tissue in vivo and in vitro. J Cardiovasc Pharmacol. 1998 Dec;32(6):875-83