同义名 :	克林霉素 盐酸盐 ;Clindamycin hydrochloride
	CAS号 :	21462-39-5
	货号 :	A203629
	分子式 :	C18H34Cl2N2O5S
	纯度 :	98%
	分子量 :	461.44
	MDL号 :	MFCD07793327
	存储条件：	Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Clindamycin hydrochloride belongs to the antibiotic family of lincomycin. It has the same antibacterial spectrum as lincomycin, but the antibacterial activity is four to eight times stronger than that of lincomycin[3]. Clindamycin is an effective antibiotic in the treatment of infections caused by certain gram-positive and gram-negative anaerobic microorganisms. Clindamycin hydrochloride is physically and chemically stable in SuspendIt for 182 days in the refrigerator and at room temperature[4]. Total clearance (CL) of clindamycin was low, after both IV and oral administration (0.503+/-0.095 vs. 0.458+/-0.087 L/h/kg). Serum clindamycin concentrations following administration of capsules remained above the MICs of very susceptible microorganisms (0.04-0.5 microg/mL) for 12 or 10 h, respectively[5]. The clindamycin regimen, after USRP (ultrasonic scaling, root planing, and polishing), had a significant effect on plaque and pocket depth measures of periodontal disease but not on gingivitis[6].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.17mL 0.43mL 0.22mL	10.84mL 2.17mL 1.08mL	21.67mL 4.33mL 2.17mL

参考文献

[1]Batzias GC, Delis GA, Athanasiou LV. Clindamycin bioavailability and pharmacokinetics following oral administration of clindamycin hydrochloride capsules in dogs. Vet J. 2005 Nov;170(3):339-45. [2]Warrick JM, Inskeep GA, et al. Effect of clindamycin hydrochloride on oral malodor, plaque, calculus, and gingivitis in dogs with periodontitis. Vet Ther. 2000 Winter;1(1):5-16. [3]Sun Q, Li Y, Qin L. Isolation and identification of two unknown impurities from the raw material of clindamycin hydrochloride. J Sep Sci. 2014;37(19):2682–2687 [4]Pramar YV, Graves RA, Ledet GA, Phan KV, Bostanian LA, Mandal TK. Stability of Clindamycin Hydrochloride in PCCA Base SuspendIt. Int J Pharm Compd. 2016;20(5):421–425 [5]Batzias GC, Delis GA, Athanasiou LV. Clindamycin bioavailability and pharmacokinetics following oral administration of clindamycin hydrochloride capsules in dogs. Vet J. 2005;170(3):339–345 [6]Nielsen D, Walser C, Kodan G, et al. Effects of treatment with clindamycin hydrochloride on progression of canine periodontal disease after ultrasonic scaling. Vet Ther. 2000;1(3):150–158