Gefitinib HCl

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Chemical Structure| 184475-55-6 同义名 : ZD-1839 hydrochloride; Gefitinib hydrochloride
CAS号 : 184475-55-6
货号 : A199522
分子式 : C22H25Cl2FN4O3
纯度 : 99%
分子量 : 483.36
MDL号 : N/A
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Gefitinib hydrochloride is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.07mL

0.41mL

0.21mL

10.34mL

2.07mL

1.03mL

20.69mL

4.14mL

2.07mL
参考文献

[1]Morgillo F, Sasso FC, et al, De Palma R, Ciardiello F. Synergistic effects of metformin treatment in combination with gefitinib, a selective EGFR tyrosine kinase inhibitor, in LKB1 wild-type NSCLC cell lines. Clin Cancer Res. 2013 Jul 1;19(13):3508-19.