Trovirdine

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Chemical Structure| 149488-17-5 同义名 : LY300046
CAS号 : 149488-17-5
货号 : A199412
分子式 : C13H13BrN4S
纯度 : 98%+
分子量 : 337.24
MDL号 : MFCD00866930
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Trovirdine inhibits HIV-1 RT with an IC50 of 7 nM when employing heteropolymeric primer/template (oligo-DNA/ribosomal RNA)and dGTP as substrate.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.97mL

0.59mL

0.30mL

14.83mL

2.97mL

1.48mL

29.65mL

5.93mL

2.97mL
参考文献

[1]Zhang, H. et al. Inhibition of human immunodeficiency virus type 1 wild-type and mutant reverse transcriptases by the phenyl ethylthiazolyl thiourea derivatives trovirdine and MSC-127.

[2]Cantrell, A.S. et al. Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs.