SU5408

产品说明书

Print
Chemical Structure| 15966-93-5 同义名 : VEGFR2 Kinase Inhibitor I
CAS号 : 15966-93-5
货号 : A198332
分子式 : C18H18N2O3
纯度 : 99%+
分子量 : 310.35
MDL号 : MFCD04974538
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. SU-5408, known as VEGFR2 Kinase Inhibitor I, is a potent, selective and cell-permeable inhibitor of mouse VEGFR2 kinase with IC50 value of 70 nM. SU5408 shows little or no effect against receptors for platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor (IC50>100 µM) [2]. 3-Substituted indolin-2-ones designed and synthesized as a novel class of tyrosine kinase inhibitors which show selectivity toward different receptor tyrosine kinases(RTKs). These compounds evaluated for their relative inhibitory properties against a panel of RTKs in intact cells. SU5408 is the most potent and selective VEGFR2 inhibitor among the compounds[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.22mL

0.64mL

0.32mL

16.11mL

3.22mL

1.61mL

32.22mL

6.44mL

3.22mL
参考文献

[1]Sun L, Tran N, et al. Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem. 1998 Jul 2;41(14):2588-603.

[2]Sun L, Tran N, Tang F, App H, Hirth P, McMahon G, Tang C. Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem. 1998 Jul 2;41(14):2588-603. doi: 10.1021/jm980123i. PMID: 9651163.