VU 0357121

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Chemical Structure| 433967-28-3 同义名 : -
CAS号 : 433967-28-3
货号 : A198314
分子式 : C17H17F2NO2
纯度 : 99%+
分子量 : 305.32
MDL号 : MFCD03243692
存储条件：

Pure form Keep in dark place, inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 VU0357121 is a positive and highly selective allosteric modulator (PAM) of mGlu5R with EC50 of 33 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.28mL

0.66mL

0.33mL

16.38mL

3.28mL

1.64mL

32.75mL

6.55mL

3.28mL
参考文献

[1]Gregory KJ, Noetzel MJ, et al. Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships. Mol Pharmacol. 2012 Nov;82(5):860-75.

[2]Hammond AS, Rodriguez AL, et al. Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology. ACS Chem Neurosci. 2010 Oct 20;1(10):702-716.