MTK458

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Chemical Structure| 2499962-58-0 同义名 : EP-0035985
CAS号 : 2499962-58-0
货号 : A1967309
分子式 : C17H15F3N4
纯度 : 98%
分子量 : 332.32
MDL号 : N/A
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 MTK458 is an orally active brain-penetrant PINK1 activator. MTK458 interacts with PINK1 and stabilizes an active heterocomplex, thereby augmenting mitophagy. MTK458 is applicable for investigating Parkinson's disease [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.01mL

0.60mL

0.30mL

15.05mL

3.01mL

1.50mL

30.09mL

6.02mL

3.01mL
参考文献

[1]Chin RM, et al. Pharmacological PINK1 activation ameliorates Pathology in Parkinson's Disease models. bioRxiv [Preprint]. 2023 Feb 15:2023.02.14.528378.