同义名 :	-
	CAS号 :	4590-86-7
	货号 :	A1964089
	分子式 :	C16H11ClN2O2
	纯度 :	99%+
	分子量 :	298.72
	MDL号 :	N/A
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性
描述	DOCK2-IN-1, analogous to CPYPP, functions as an inhibitor targeting the DOCK2 enzyme, with an IC50 of 19.1 μM. It engages the DOCK2 DHR-2 domain reversibly, impeding its catalytic function. This inhibitor effectively halts the activation of Rac, a GTPase, by both chemokine and antigen receptors in lymphocytes, thereby substantially diminishing chemotactic responses and T cell activation[1].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	3.35mL 0.67mL 0.33mL	16.74mL 3.35mL 1.67mL	33.48mL 6.70mL 3.35mL

参考文献
[1]Nishikimi A, et al. Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem Biol. 2012 Apr 20;19(4):488-97.