JNJ-40411813

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Chemical Structure| 1127498-03-6 同义名 : ADX-71149
CAS号 : 1127498-03-6
货号 : A196362
分子式 : C20H25ClN2O
纯度 : 99%+
分子量 : 344.88
MDL号 : MFCD22572363
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 JNJ-40411813 (ADX-71149) is a novel positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R), with an EC50 of 147 nM, showcasing oral bioactivity and the ability to cross the blood-brain barrier. JNJ-40411813 has the potential property of anti-depression[1].[2].[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.90mL

0.58mL

0.29mL

14.50mL

2.90mL

1.45mL

29.00mL

5.80mL

2.90mL
参考文献

[1]Cid JM, et al. Discovery of 1-Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor. J Med Chem. 2014 Aug 14;57(15):6495-512.

[2]Hilde Lavreysen, et al. Pharmacological and pharmacokinetic properties of JNJ-40411813, a positive allosteric modulator of the mGlu2 receptor. Pharmacol Res Perspect 2015 Feb;3(1):e00096.

[3]Dunlop J, Schizophrenia, et al. Schizophrenia drug discovery and development in an evolving era: are new drug targets fulfilling expectations?. Journal of Psychopharmacology. 29 (2): 230–8.