GSK1059615

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Chemical Structure| 958852-01-2 同义名 : -
CAS号 : 958852-01-2
货号 : A195657
分子式 : C18H11N3O2S
纯度 : 98%
分子量 : 333.36
MDL号 : MFCD18074517
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
靶点

  • mTOR

    mTOR, IC50:12 nM

  • p110β

    PI3Kβ, IC50:0.6 nM

  • p110δ

    PI3Kδ, IC50:2 nM

  • p110α

    PI3Kα, IC50:0.4 nM

  • p110γ

    PI3Kγ, IC50:5 nM
描述 GSK1059615 is a dual inhibitor of PI3Kα/β/δ/γ (reversible) and mTOR with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.00mL

0.60mL

0.30mL

15.00mL

3.00mL

1.50mL

30.00mL

6.00mL

3.00mL
参考文献

[1]Maira SM, Finan P, et al. From the bench to the bed side: PI3K pathway inhibitors in clinical development. Curr Top Microbiol Immunol. 2010;347:209-39.

[2]Carnero A. Novel inhibitors of the PI3K family. Expert Opin Investig Drugs. 2009 Sep;18(9):1265-77.