Zongertinib

产品说明书

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Chemical Structure| 2728667-27-2 同义名 : BI 1810631
CAS号 : 2728667-27-2
货号 : A1942329
分子式 : C29H29N9O2
纯度 : 98%
分子量 : 535.6
MDL号 : N/A
存储条件:

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 Zongertinib (BI 1810631) is a potent and selective inhibitor of HER2 and EGFR tyrosine kinases, with IC50 values of 13 nM and 579 nM, respectively. It exhibits antitumor activity and holds promise for research in various solid tumors [1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.87mL

0.37mL

0.19mL

9.34mL

1.87mL

0.93mL

18.67mL

3.73mL

1.87mL

参考文献

[1]Jones J, et al. Selective Inhibition of NaV1.8 with VX-548 for Acute Pain. N Engl J Med. 2023 Aug 3;389(5):393-405.

[2]WHO Drug Information-World Health Organization (WHO).

[3]Li S, et al. Emerging Targeted Therapies in Advanced Non-Small-Cell Lung Cancer. Cancers (Basel). 2023 May 24;15(11):2899.