R 59-022 HCl
产品说明书
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同义名 : | DKGI-I hydrochloride; Diacylglycerol kinase inhibitor I hydrochloride |
| CAS号 : | 93076-98-3 | |
| 货号 : | A1938044 | |
| 分子式 : | C27H27ClFN3OS | |
| 纯度 : | 98%+ | |
| 分子量 : | 496.04 | |
| MDL号 : | N/A | |
| 存储条件： |
Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | R 59-022 hydrochloride is a DGK inhibitor with an IC50 value of 2.8 µM. R 59-022 hydrochloride inhibits the phosphorylation of OAG to OAPA. R 59-022 hydrochloride is a 5-HT receptor antagonist that activates PKC. R 59-022 hydrochloride enhances thrombin-induced platelet diacylglycerol production and inhibits phosphatidic acid production in neutrophils[1][2][3][4].At a concentration of 10 μM for 1 min, R 59-022 hydrochloride enhances aggregation induced by sub-maximal concentrations of thrombin but fails to change shape[2].At a concentration of 30 μM for 0-60 min, R 59-022 hydrochloride increases the release of norepinephrine from chromaffin cells[3].At a concentration of 40 μM for 30 min, R 59-022 hydrochloride activated PKC in HeLa and U87 cells[4].At a concentration of 0-10 μM for 4 hours, R 59-022 hydrochloride blocked the entry of EBOV GP-mediated viruses into Vero cells[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.02mL 0.40mL 0.20mL |
10.08mL 2.02mL 1.01mL |
20.16mL 4.03mL 2.02mL |
