PS-48

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Chemical Structure| 1180676-32-7 同义名 : -
CAS号 : 1180676-32-7
货号 : A193586
分子式 : C17H15ClO2
纯度 : 99%+
分子量 : 286.75
MDL号 : MFCD17215962
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 PS48 is a phosphoinositide-dependent protein kinase-1 (PDK1) activator with Kd value of 10.3 μM and binds exclusively to the PIF-binding pocket of PDK1, distinct from the ATP binding site.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.49mL

0.70mL

0.35mL

17.44mL

3.49mL

1.74mL

34.87mL

6.97mL

3.49mL
参考文献

[1]Spate LD, Brown A, et al. PS48 can replace bovine serum albumin in pig embryo culture medium, and improve in vitro embryo development by phosphorylating AKT. Mol Reprod Dev. 2015 Apr;82(4):315-20.

[2]Hindie V, Stroba A, et al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat Chem Biol. 2009 Oct;5(10):758-64.