AS8351
产品说明书
 |
同义名 : | NSC51355; NCI 51355 |
| CAS号 : | 796-42-9 | |
| 货号 : | A1932733 | |
| 分子式 : | C17H13N3O2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 291.3 | |
| MDL号 : | MFCD00033110 | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | AS8351, also known as NSC51355, is an inhibitor of KDM5B that promotes and maintains active chromatin configurations, aiding in the generation of cells resembling cardiomyocytes[1]. It intervenes in epigenetic alterations by vying with α-ketoglutarate (α-KG) to bind iron [Fe(II)], which is essential for the function of certain epigenetic enzymes, including JmjC domain-containing histone demethylases (JmjC-KDMs) that depend on α-KG and iron as cofactors[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.43mL 0.69mL 0.34mL |
17.16mL 3.43mL 1.72mL |
34.33mL 6.87mL 3.43mL |
