Luzindole
产品说明书
 |
同义名 : | N-0774 |
| CAS号 : | 117946-91-5 | |
| 货号 : | A192769 | |
| 分子式 : | C19H20N2O | |
| 纯度 : | 98% | |
| 分子量 : | 292.37 | |
| MDL号 : | MFCD00672498 | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Luzindole, identified as N-0774, acts as a melatonin receptor blocker with a higher affinity for MT2 (Mel1b) receptors compared to MT1 (Mel1a), demonstrated by Ki values of 10.2 nM for MT2 and 158 nM for MT1. It has been found to inhibit the progression of experimental autoimmune encephalomyelitis (EAE) and display properties akin to antidepressants[1][2][3]. Additionally, Luzindole at concentrations ranging from 5-10 μg/ml effectively hinders the antigen-specific growth of the MBP-responsive LV-4 T cell line[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.42mL 0.68mL 0.34mL |
17.10mL 3.42mL 1.71mL |
34.20mL 6.84mL 3.42mL |
