740 Y-P
产品说明书
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同义名 : | 740YPDGFR; PDGFR 740Y-P |
| CAS号 : | 1236188-16-1 | |
| 货号 : | A192145 | |
| 分子式 : | C141H222N43O39PS3 | |
| 纯度 : | 98% | |
| 分子量 : | 3270.7 | |
| MDL号 : | MFCD07784548 | |
| 存储条件： |
Pure form Inert atmosphere, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | 740 Y-P acts as a cell-permeable phosphopeptide activator of PI3K. It improved both the mitogenic response in C2 muscle cells and survival of cerebellar granule neurons at 50μg/ml, which can be inhibited by wortmannin and rapamycin. Correlated with its action on PI3K, the phosphorylation of Akt, which is an established downstream effector in the PI 3-kinase survival cascade, could be observed post 1h-treatment with 740 Y-P at the concentration of 25μg/ml. Pretreatment with 740 Y-P at 1.53 µM for 30min alleviated the cytolysis of cultured rat neurons induced by sera or IgG of children with Opsoclonus-myoclonus syndrome and neuroblastoma. | ||
| 作用机制 | 740 Y-P is a peptide that can mimic the phosphorylation of PDGF receptor and bind to the p85 SH2 domain with high affinity. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
0.31mL 0.06mL 0.03mL |
1.53mL 0.31mL 0.15mL |
3.06mL 0.61mL 0.31mL |
| 参考文献 |
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