同义名 :	Carboxine; Fenoxan; D 735; Cerevax; CCRIS 5217; Kisvax; Vitavax; Carbathiin
	CAS号 :	5234-68-4
	货号 :	A189867
	分子式 :	C12H13NO2S
	纯度 :	98%
	分子量 :	235.3
	MDL号 :	MFCD00055403
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Carboxin (Carboxine) is a systemic agricultural fungicide and seed protectant. Carboxin demonstrates high specificity against the fungal class Basideomycetes, Deuteromycetes and Phycomycetes[1]. Carboxin is a potent inhibitor of the enzyme of certain organisms. The bacterium Paracoccus denitrificans was found to be sensitive to carboxin in vivo, and mutants that grow in the presence of 3'-methyl carboxin were isolated[2]. The systemic fungicide carboxin (5,6-dihydro-2-methyl-1,4-oxathiin-3-carboxanilide) inhibited oxidation of succinate by membranes prepared from Micrococcus denitrificans, the K(i) being 16 muM. Carboxin also inhibited dichlorophenol indophenol (DCIP) reductase activities in a manner both qualitatively and quantitatively similar to the inhibition of oxidation of the various substrates[3].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	4.25mL 0.85mL 0.42mL	21.25mL 4.25mL 2.12mL	42.50mL 8.50mL 4.25mL

参考文献

[1]Frampton CS, Frampton ES, Thomson PA. Two polymorphic forms of the oxathiin systemic fungicide active carboxine. Acta Crystallogr E Crystallogr Commun. 2018;74(Pt 12):1741-1745. Published 2018 Nov 9 [2]Matsson M, Ackrell BA, Cochran B, Hederstedt L. Carboxin resistance in Paracoccus denitrificans conferred by a mutation in the membrane-anchor domain of succinate:quinone reductase. Arch Microbiol. 1998 Jul;170(1):27-37 [3]Tucker AN, Lillich TT. Effect of the systemic fungicide carboxin on electron transport function in membranes of Micrococcus denitrificans. Antimicrob Agents Chemother. 1974 Nov;6(5):572-8