ONO-AE3-208

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Chemical Structure| 402473-54-5 同义名 : AE 3-208
CAS号 : 402473-54-5
货号 : A187661
分子式 : C24H21FN2O3
纯度 : 98%
分子量 : 404.43
MDL号 : MFCD13184814
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 ONO-AE3-208 is an EP4 antagonist, and suppresses cell invasion, migration, and metastasis of prostate cancer. The in vivo bone metastasis of PC3 was also suppressed by ONO-AE3-208 treatment[3]. Hypoxia-enhanced functions in miRNA-high cells are inhibited by COX-2 inhibitor (Celecoxib), EP4 antagonist (ONO-AE3-208), and irreversible PI3K/Akt inhibitor (Wortmannin)[4]. EP4 antagonism (ONO AE3-208) improves the NTS (nephrotoxic serum nephritis) phenotype, probably by decreasing mainly Cxcl-5 production in tubular cells, thereby reducing renal neutrophil infiltration[5]. Intravesical application of ONO-AE3-208 (30 μm), but not vehicle application, significantly increased ICIs (intercontraction intervals) in rats with prostatic inflammation, whereas ONO-AE3-208 at this concentration did not significantly affect any cystometric values in control rats[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.47mL

0.49mL

0.25mL

12.36mL

2.47mL

1.24mL

24.73mL

4.95mL

2.47mL
参考文献

[1]Xu S, Zhang Z, et al. An EP4 antagonist ONO-AE3-208 suppresses cell invasion, migration, and metastasis of prostate cancer. Cell Biochem Biophys. 2014 Sep;70(1):521-7.

[2]Ren Y, D'Ambrosio MA, et al. Prostaglandin E2 mediates connecting tubule glomerular feedback. Hypertension. 2013 Dec;62(6):1123-8.

[3]Xu S, Zhang Z, Ogawa O, Yoshikawa T, Sakamoto H, Shibasaki N, Goto T, Wang L, Terada N. An EP4 antagonist ONO-AE3-208 suppresses cell invasion, migration, and metastasis of prostate cancer. Cell Biochem Biophys. 2014 Sep;70(1):521-7

[4]Gervin E, Shin B, Opperman R, Cullen M, Feser R, Maiti S, Majumder M. Chemically Induced Hypoxia Enhances miRNA Functions in Breast Cancer. Cancers (Basel). 2020 Jul 22;12(8):2008

[5]Aringer I, Artinger K, Kirsch AH, Schabhüttl C, Jandl K, Bärnthaler T, Mooslechner AA, Herzog SA, Uhlig M, Kirsch A, Frank S, Banas M, Pollheimer M, Eller P, Rosenkranz AR, Heinemann A, Eller K. Blockade of prostaglandin E2 receptor 4 ameliorates nephrotoxic serum nephritis. Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1869-F1880

[6]Mizoguchi S, Wolf-Johnson AS, Ni J, Mori K, Suzuki T, Takaoka E, Mimata H, DeFranco DB, Wang Z, Birder LA, Yoshimura N. The role of prostaglandin and E series prostaglandin receptor type 4 receptors in the development of bladder overactivity in a rat model of chemically induced prostatic inflammation. BJU Int. 2019 Nov;124(5):883-891