HMN-176

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Chemical Structure| 173529-10-7 同义名 : -
CAS号 : 173529-10-7
货号 : A186241
分子式 : C20H18N2O4S
纯度 : 98%
分子量 : 382.43
MDL号 : MFCD00945108
存储条件：

Pure form Keep in dark place, inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 HMN-176 is a stilbene derivative which inhibits mitosis without significant effect on tubulin polymerization.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.61mL

0.52mL

0.26mL

13.07mL

2.61mL

1.31mL

26.15mL

5.23mL

2.61mL
参考文献

[1]DiMaio MA, Mikhailov A, et al. The small organic compound HMN-176 delays satisfaction of the spindle assembly checkpoint by inhibiting centrosome-dependent microtubule nucleation. Mol Cancer Ther. 2009 Mar;8(3):592-601.

[2]Medina-Gundrum L, Cerna C, et al. Investigation of HMN-176 anticancer activity in human tumor specimens in vitro and the effects of HMN-176 on differential gene expression. Invest New Drugs. 2005 Jan;23(1):3-9.

[3]Takagi M, Honmura T, et al. In vivo antitumor activity of a novel sulfonamide, HMN-214, against human tumor xenografts in mice and the spectrum of cytotoxicity of its active metabolite, HMN-176. Invest New Drugs. 2003 Nov;21(4):387-99.