VU0152100

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Chemical Structure| 409351-28-6 同义名 : VU152100
CAS号 : 409351-28-6
货号 : A184076
分子式 : C18H19N3O2S
纯度 : 99%+
分子量 : 341.43
MDL号 : MFCD02742972
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 VU0152100 (VU152100) is a highly selective mAChR positive allosteric modulator that crosses the blood-brain barrier. It counteracts Amphetamine-induced hypermotility in rats and elevates extracellular dopamine levels in the nucleus accumbens and caudate-putamen. VU0152100 shows significant research potential for treating psychosis and cognitive impairment related to mental disorders like schizophrenia[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.93mL

0.59mL

0.29mL

14.64mL

2.93mL

1.46mL

29.29mL

5.86mL

2.93mL
参考文献

[1]Byun NE, et al. Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100. Neuropsychopharmacology. 2014 Jun;39(7):1578-93.

[2]Brady AE, et al. Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J Pharmacol Exp Ther. 2008 Dec;327(3):941-53.