同义名 :	盐酸金刚烷胺 ;1-Aminoadamantane hydrochloride; 1-Adamantylamine hydrochloride; NSC 83653; Aminoadamantane; Adamantylamine; Amantadine (hydrochloride); Amantadine HCl; 1-Adamantanamine hydrochloride; Amantadine hydrochloride
	CAS号 :	665-66-7
	货号 :	A183434
	分子式 :	C10H18ClN
	纯度 :	98%
	分子量 :	187.71
	MDL号 :	MFCD00074723
	存储条件：	Pure form Inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

1-Adamantanamine Hydrochloride (amantadine hydrochloride), as a pro-dopaminergic drug and as an N-methyl-D-aspartate antagonist, makes amantadine an interesting candidate to improve consciousness and responsiveness in individuals with DOC (disorders of consciousness), including vegetative state and minimally conscious state[3]. 1-Adamantanamine hydrochloride (aminoadamantane) has been shown to inhibit the multiplication of influenza A viruses in cell cultures, organ cultures and experimentally infected mice. In a double-blind, placebo-controlled investigation of aminoadamantane given prophylactically, in doses of 100 mg every 12 hours for 10 days, no protective effect of the drug was demonstrated[4]. I-Adamantanamine hydrochloride, added to chick embryo cells, inhibited focus production upon subsequent inoculation of the cells with Rous and Esh sarcoma viruses. 1-adamantanamine hydrochloride are capable of supporting viral replication, the drug inhibits growth of two oncogenic viruses by prevention of virus penetration, but not by a virucidal effect or cell intoxication[5].

临床研究
NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00513292	HER2/Neu Positive ... 展开 >> Stage IA Breast Cancer Stage IB Breast Cancer Stage II Breast Cancer Stage IIIA Breast Cancer 收起 <<	Phase 3	Unknown	-	-
NCT01441986	Type 2 Diabetes Mellitus	Phase 2	Completed	-	Germany ... 展开 >> Profil Institute for Metabolic Research Neuss, NRW, Germany, 41460 收起 <<
NCT00513292	-		Unknown	-	-

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	5.33mL 1.07mL 0.53mL	26.64mL 5.33mL 2.66mL	53.27mL 10.65mL 5.33mL

参考文献

[1]Salom, D., Hill BR, et al., pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus. Biochemistry, 2000. 39(46): p. 14160-70. [2]Salom, D., Hill BR, et al., pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus. Biochemistry, 2000. 39(46): p. 14160-70. [3]Formisano R, Zasler ND. Posttraumatic parkinsonism. J Head Trauma Rehabil. 2014;29(4):387‐390 [4]Galbraith AW, Oxford JS, Schild GC, Watson GI. Study of 1-adamantanamine hydrochloride used prophylactically during the Hong Kong influenza epidemic in the family environment. Bull World Health Organ. 1969;41(3):677‐682 [5]Wallbank AM, Matter RE, Klinikowski NG. 1-Adamantanamine hydrochloride: inhibition of Rous and Esh Sarcoma viruses in cell culture. Science. 1966;152(3730):1760‐1761