Thymine
产品说明书
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同义名 : | 胸腺嘧啶 ;5-methyluracil |
| CAS号 : | 65-71-4 | |
| 货号 : | A178972 | |
| 分子式 : | C5H6N2O2 | |
| 纯度 : | 97% | |
| 分子量 : | 126.11 | |
| MDL号 : | MFCD00006026 | |
| 存储条件： |
Pure form Sealed in dry, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM. Total inhibition of 5-FU degradation occurred at a uridine concentration of 10 microM, whereas thymidine was found to be a much less potent noncompetitive inhibitor of pyrimidine base degradation (Ki 24 microM) [2]. Thymine methyls can provide contact points via van der Waals interactions with amino acid side chains of specific DNA binding proteins[3]. The new base modification (Trex , thymine ring expunged) can form under physiological conditions, and is resistant to the action of common repair machineries[4]. Oxidation of DNA causes chemical reactions that result in remote damage (mutation) to a nucleobase. Normally this reaction occurs at guanine, but in oligonucleotides that lack guanines, or when the DNA contains a thymine-thymine mispair, reaction occurs primarily at thymine notwithstanding its high oxidation potential[5]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
7.93mL 1.59mL 0.79mL |
39.65mL 7.93mL 3.96mL |
79.30mL 15.86mL 7.93mL |
| 参考文献 |
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